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Total 155181 results found since Jan 2013.

Dipeptidyl-peptidase-4 inhibitors have anti-inflammatory effects in patients with type 2 diabetes
ConclusionThis meta-analysis demonstrated that DPP-4 inhibitors can significantly attenuate low-grade inflammatory state in patients with T2DM. In addition to improving glycemic control, DDP-4 inhibitors might offer extra therapeutic value by controlling inflammation.Graphical Abstract
Source: European Journal of Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Source Type: research

Impact of tofogliflozin on hepatic outcomes: a systematic review
ConclusionOverall, an improvement in levels of hepatic parameters was observed in T2DM patients with concurrent liver disorders. However, a large number of clinical trials are needed to prove the efficacy of tofogliflozin on hepatic outcomes in patients with T2DM.
Source: European Journal of Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Source Type: research

Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma
Endocrinology. 2023 Sep 20:bqad139. doi: 10.1210/endocr/bqad139. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the most common malignancies with high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the treatment of diabetes, and recent studies have shown that metformin has a remarkable suppressive effect on tumor progression. Metformin can...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Jiayi Liu Jing Zhao Xue Qiao Source Type: research

New insights on the potential anti-epileptic effect of metformin: Mechanistic pathway
In conclusion, metformin might be an adjuvant with AEAs in the management of refractory epilepsy. Preclinical and clinical studies are warranted in this regard.PMID:37737447 | DOI:10.1111/jcmm.17965
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Saud A Alnaaim Hayder M Al-Kuraishy Ali I Al-Gareeb Naif H Ali Athanasios Alexiou Marios Papadakis Hebatallah M Saad Gaber El-Saber Batiha Source Type: research

Inhibition of STIM1 alleviates high glucose-induced proliferation and fibrosis by inducing autophagy in mesangial cells
In this study, we investigated the role of STIM1 in the proliferation and fibrosis in high glucose (HG)-induced HBZY-1 cells. We found that the expression of STIM1 was increased in renal tissues of diabetic rat and HBZY-1 cells stimulated by HG. Downregulation of STIM1-mediated SOCE suppressed hyperglycemic cell proliferation and fibrosis by activating autophagy. In addition, the inhibitory effect of downregulating STIM1 on cells was blocked by autophagy inhibitor Bafilomycin A1 (BafA1). Moreover, this experiment also showed that STIM1 regulated autophagy, cell proliferation and fibrosis via PI3K/AKT/mTOR signal pathway. T...
Source: Molecular and Cellular Biochemistry - September 22, 2023 Category: Biochemistry Authors: Xixi Zeng Anbang Sun Weiyi Cheng Xin Hou Min Zhu Yanhong Liao Source Type: research

Fetal Exposure to Preeclampsia and Later Risk of Cardiometabolic Disorders: A Population-Based Cohort Study
CONCLUSIONS: Fetal preeclampsia exposure was associated with adult life hypertension, diabetes, and dyslipidemia, but these associations were likely due to shared etiological factors, rather than exposure to the preeclamptic condition itself.PMID:37737002 | DOI:10.1161/HYPERTENSIONAHA.122.20682
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Abira Paramsothy Tor-Arne Hegvik Anders Engeland Tone Bj ørge Grace M Egeland Kari Klungs øyr Source Type: research

Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells
Conclusions: High resolution chromatin interaction profiles at selectively targeted loci can complement genome- and promoter-wide maps.PMID:37736013 | PMC:PMC10509606 | DOI:10.12688/wellcomeopenres.18653.2
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Jason M Torres Han Sun Vibe Nylander Damien J Downes Martijn van de Bunt Mark I McCarthy Jim R Hughes Anna L Gloyn Source Type: research

Designing Stimuli-Responsive Upconversion Nanoparticles Based on a Mimetic Immunoassay for Potential Diabetic Nephropathy Accuracy Diagnosis
Analyst, 2023, Accepted Manuscript DOI: 10.1039/D3AN01041D, PaperYiting Wang, Yang Hu, Ru Wang, Wei Zhang, Huiting Mao, Chuanjun Yuan, Ruinian Hua Diabetic nephropathy (DN) is the most common microvascular complication associated with incurable diabetes. The gold standard diagnostic method for DN is based on the detection of proteinuria but it overlooks... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - September 22, 2023 Category: Chemistry Authors: Yiting Wang Source Type: research

MG53 does not mark cardiovascular risk and all-cause mortality in subjects with type 2 diabetes: a prospective, observational study
Subjects with type 2 diabetes (T2D) are characterized by a high cardiovascular morbidity and mortality. MG53, a marker of peripheral insulin resistance, has been linked with impaired β-cell function and decreased β-cell survival, and its circulating levels are increased in T2D. Its relationship with the cardiovascular risk profile and mortality in T2D is currently unknown.
Source: Diabetes Research and Clinical Practice - September 22, 2023 Category: Endocrinology Authors: Cristina Bianchi, Olga Vaccaro, Mariarosaria Distaso, Laura Franzini, Francesco Raggi, Anna Solini Source Type: research

Antenatal corticosteroids in specific groups at risk of preterm birth: a systematic review
Conclusions There is a paucity of evidence on ACS for women who have diabetes. ACS therapy may have benefits in women with chorioamnionitis and is probably beneficial in FGR. There is limited direct trial evidence on ACS efficacy in women undergoing planned CS in the late preterm period, though the totality of evidence suggests it is probably beneficial. PROSPERO registration number CRD42021267816.
Source: BMJ Open - September 22, 2023 Category: General Medicine Authors: Saito, K., Nishimura, E., Ota, E., Namba, F., Swa, T., Ramson, J., Lavin, T., Cao, J., Vogel, J. P. Tags: Open access, Paediatrics Source Type: research

A Systematic Review of Methodologies Used in Models of the Treatment of Diabetes Mellitus
ConclusionsModels developed in the past 12 years for health economic evaluations of diabetes treatments are of high-quality and make use of advanced methods. However, further developments are needed to improve the statistical modelling component of cost-effectiveness models and to provide better assessment of structural uncertainty.
Source: PharmacoEconomics - September 22, 2023 Category: Health Management Source Type: research

Case Report: A rare case of non-small cell lung cancer with STRN-ALK fusion in a patient in very poor condition treated with first-line ensartinib
Several cases of STRN-ALK fusion have been reported, and some anaplastic lymphoma kinase (ALK) inhibitors have been shown to be effective for treatment. Nevertheless, no cases of COVID-19 leading to heart failure and respiratory failure have been reported in people older than 70 years treated with ALK inhibitors. The present case report describes a 70-year-old patient with usual chronic obstructive pulmonary disease, diabetes, depression, and carotid plaque disease. Next-generation sequencing of tissue obtained by puncture biopsy revealed a STRN-ALK mutation accompanied by a TP53 mutation. The patient was treated with ensa...
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research

Viruses, Vol. 15, Pages 1975: Alterations in Patients & rsquo; Clinical Outcomes and Respiratory Viral Pathogen Activity following the COVID-19 Pandemic
Conclusions: We have demonstrated a reduction in the detection of several viruses, which might be due to the increase in public awareness toward infection protection measures after the COVID-19 pandemic.
Source: Viruses - September 22, 2023 Category: Virology Authors: Khaled Al Oweidat Ahmad A. Toubasi Ahmad Alghrabli Yasmeen Khater Noor Saleh Asma S. Albtoosh Rawan Shafeek Batarseh Tags: Article Source Type: research

Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug
The SENS Research Foundation staff have carried out the public service of extensively discussing and dismantling the evidence commonly cited in support of metformin as a way to modestly slow aging, showing that said evidence is problematic, to say the least. Metformin might make life modestly better for diabetics, but it doesn't slow aging. This view of the human data matches the poor quality of the animal model data, in which metformin makes a poor showing in comparison to the robust data for a modest slowing of aging that is produced by the use of, say, mTOR inhibitors, or the practice of calorie restriction. Rega...
Source: Fight Aging! - September 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer
ConclusionsAnagliptin can enhance PD-L1 blockade efficacy in NSCLC by inhibiting macrophage differentiation and M2 macrophage polarization, and combination therapy may be a promising strategy for treating PD-L1 blockade therapy-resistant patients with NSCLC.
Source: Clinical and Translational Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research